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SNPs, HapMap, and common disease

Julian C. Knight

in Human Genetic Diversity: Functional Consequences for Health and Disease

Published in print:
2009
Published Online:
September 2009
ISBN:
9780199227693
eISBN:
9780191711015
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199227693.003.0009
Subject:
Biology, Evolutionary Biology / Genetics, Disease Ecology / Epidemiology

The extent of single nucleotide polymorphism is reviewed, together with insights gained into the nature of allelic architecture in terms of haplotypes, linkage disequilibrium and recombination. The ... More


Invalids and entrepreneurs

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0010
Subject:
History, British and Irish Early Modern History

Chapter 9 explores the medical marketplace of early nineteenth‐century Britain, with particular reference to tropical invalids and others deemed to have similar complaints. The chapter focuses on the ... More


The voyager returns

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0011
Subject:
History, British and Irish Early Modern History

This chapter examines some of the themes arising from earlier chapters through the career of James Johnson, one of the most influential practitioners of his day. After his retirement from the Royal ... More


Albion's coast is sick

Mark Harrison

in Medicine in an age of Commerce and Empire: Britain and its Tropical Colonies 1660-1830

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199577736
eISBN:
9780191595196
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199577736.003.0012
Subject:
History, British and Irish Early Modern History

Chapter 11 examines the career of the naval physician Thomas Trotter, who claimed that two‐thirds of the population were suffering the ill‐effects of luxury and nervous over‐stimulation. He believed ... More


Axonal degeneration and disorders of the axonal cytoskeleton

JOHN W. GRIFFIN, EDWIN B. GEORGE, SUNG-TSANG HSIEH, and JONATHAN D. GLASS

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0020
Subject:
Neuroscience, Disorders of the Nervous System

This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding ... More


Modern Urban Lifestyles, Degeneration, and the Male Body

Ina Zweiniger‐Bargielowska

in Managing the Body: Beauty, Health, and Fitness in Britain 1880-1939

Published in print:
2010
Published Online:
January 2011
ISBN:
9780199280520
eISBN:
9780191594878
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199280520.003.0002
Subject:
History, British and Irish Modern History

This chapter charts the emergence of life reform, vegetarianism, physical culture, and reducing culture, which have to be understood against the background of rapid urbanization, the rise of modern ... More


NONIDEAL PLASMA. BASIC CONCEPTS

V. E. Fortov, I. T. Iakubov, and A. G. Khrapak

in Physics of Strongly Coupled Plasma

Published in print:
2006
Published Online:
September 2007
ISBN:
9780199299805
eISBN:
9780191714948
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199299805.003.0001
Subject:
Physics, Nuclear and Plasma Physics

This introductory chapter discusses different types of interparticle interactions (Coulomb, electron-atom, and ion-atom) and the criteria of nonideality. The classification of states is given and the ... More


Down's Syndrome

DAVID WRIGHT

in Mental Disability in Victorian England: The Earlswood Asylum 1847-1901

Published in print:
2001
Published Online:
January 2010
ISBN:
9780199246397
eISBN:
9780191715235
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199246397.003.010
Subject:
History, British and Irish Modern History

Within traditional medical history, John Langdon Down is seen as a physician who was ‘in advance of his time’ in the treatment and classification of persons with mental disabilities. He was ... More


Nervous Degeneration

Janet Oppenheim

in “Shattered Nerves”: Doctors, Patients, and Depression in Victorian England

Published in print:
1991
Published Online:
October 2011
ISBN:
9780195057812
eISBN:
9780199854394
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195057812.003.0009
Subject:
History, British and Irish Modern History

In 1905, the idea of nervous degeneration was inseparable from the more open discussion of moral degradation and physical debility. For a country beleaguered by worldwide competitors, nerves were ... More


The neuropsychological presentation of Alzheimer’s disease and other neurodegenerative disorders

Julie Snowden

in The Handbook of Clinical Neuropsychology

Published in print:
2010
Published Online:
September 2010
ISBN:
9780199234110
eISBN:
9780191594250
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199234110.003.028
Subject:
Psychology, Neuropsychology, Clinical Psychology

Alzheimer's disease and other neurodegenerative diseases that lead to progressive cognitive impairment are conventionally classified as ‘the dementias’. Dementia is traditionally defined as a ... More


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