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The Promise of Computational Psychiatry

Jeffrey Poland and Michael Frank

in Extraordinary Science and Psychiatry: Responses to the Crisis in Mental Health Research

Published in print:
2017
Published Online:
September 2017
ISBN:
9780262035484
eISBN:
9780262341752
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035484.003.0006
Subject:
Psychology, Clinical Psychology

This chapter begins with the assumptions of the present volume that a crisis exists in psychiatric research and that research concerning mental illness has entered a period of “extraordinary ... More


Computational Psychiatry: New Perspectives on Mental Illness

A. David Redish and Joshua A. Gordon (eds)

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.001.0001
Subject:
Psychology, Cognitive Neuroscience

Psychiatry is at a crossroads. Faced with challenges of diagnosis and treatment, it must balance analyses at both neurological and psychological levels. Issues of comorbidity, treatment stability, ... More


Breakdowns and Failure Modes: An Engineer’s View

A. David Redish and Joshua A. Gordon

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0002
Subject:
Psychology, Cognitive Neuroscience

Psychiatry faces a number of challenges due largely to the complexity of the relationship between mind and brain. Starting from the now well-justified assumption that the mind is instantiated in the ... More


Complexity and Heterogeneity in Psychiatric Disorders: Opportunities for Computational Psychiatry

Nelson Totah, Huda Akil, Quentin J. M. Huys, John H. Krystal, Angus W. MacDonald, Tiago V. Maia, Robert C. Malenka, and Wolfgang M. Pauli

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0003
Subject:
Psychology, Cognitive Neuroscience

Psychiatry faces numerous challenges: the reconceptualization of symptoms and diagnoses, disease prevention, treatment development and monitoring of its effects, and the provision of individualized, ... More


Computational Approaches for Studying Mechanisms of Psychiatric Disorders

Zeb Kurth-Nelson, John P. O’Doherty, Deanna M. Barch, Sophie Denève, Daniel Durstewitz, Michael J. Frank, Joshua A. Gordon, Sanjay J. Mathew, Yael Niv, Kerry Ressler, and Heike Tost

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0005
Subject:
Psychology, Cognitive Neuroscience

Vast spectra of biological and psychological processes are potentially involved in the mechanisms of psychiatric illness. Computational neuroscience brings a diverse toolkit to bear on understanding ... More


Call for Pragmatic Computational Psychiatry: Integrating Computational Approaches and Risk-Prediction Models and Disposing of Causality

Martin P. Paulus, Crane Huang, and Katia M. Harlé

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0014
Subject:
Psychology, Cognitive Neuroscience

Biological psychiatry is at an impasse. Despite several decades of intense research, few, if any, biological parameters have contributed to a significant improvement in the life of a psychiatric ... More


A Valuation Framework for Emotions Applied to Depression and Recurrence

Quentin J. M. Huys

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0015
Subject:
Psychology, Cognitive Neuroscience

The burden of depression is substantially aggravated by relapses and recurrences, and these become more inevitable with every episode of depression. This chapter describes how computational ... More


On the Cusp: Current Challenges and Promises in Psychiatry

Joshua A. Gordon and A. David Redish

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0001
Subject:
Psychology, Cognitive Neuroscience

Modern psychiatry seeks to treat disorders of the brain, the most complex and least understood organ in the human body. This complexity poses a set of challenges that make progress in psychiatric ... More


What Does Computational Psychiatry Need to Explain to Capture Mechanisms of Psychopathology?: Facts, Almost Facts, and Hints

Deanna M. Barch

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0004
Subject:
Psychology, Cognitive Neuroscience

This chapter provides specific research examples on the neurobiology of mental illness—using psychosis as a case in point—that may begin to rise to the level of “facts,” or at least “almost facts” or ... More


Computational Cognitive Neuroscience Approaches to Deconstructing Mental Function and Dysfunction

Michael J. Frank

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0006
Subject:
Psychology, Cognitive Neuroscience

Advances in our understanding of brain function and dysfunction require the integration of heterogeneous sources of data across multiple levels of analysis, from biophysics to cognition and back. ... More


How Could We Get Nosology from Computation?

Christoph Mathys

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0007
Subject:
Psychology, Cognitive Neuroscience

Psychiatry has found it difficult to develop a nosology that allows for the targeted treatment of disorders of the mind. This article sets out a possible way forward: harnessing systems theory to ... More


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