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NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

W. Otto Friesen and Jonathon Friesen

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.001.0001
Subject:
Psychology, Cognitive Neuroscience

The electrical membrane potential is an important property for the functioning of living cells. Temporal variations of this potential generated by synaptic interactions and expressed as nerve ... More


Axon Models

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0011
Subject:
Psychology, Cognitive Neuroscience

The Axon model simulates the equations and parameters derived from experiments by Hodgkin and Huxley on the squid giant axon. Because of the exact correspondence between the equations incorporated ... More


Equations Underlying the Patch Model

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0017
Subject:
Psychology, Cognitive Neuroscience

The Patch model illustrates results obtained from patch-clamp experiments. This chapter describes the elementary equations for currents through individual ion channels, based on Ohm's law. Because ... More


Equations Underlying the Axon Models

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0019
Subject:
Psychology, Cognitive Neuroscience

The Axon models present the fundamental concepts that underlie the generation and propagation of the nerve impulses. This chapter includes a complete list of the equations that describe the ... More


Patch Model

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0009
Subject:
Psychology, Cognitive Neuroscience

The Patch model simulates the dynamics of a small piece of cell membrane as observed with the patch-clamp technique. Either individual channels in a small patch of membrane or the macroscopic current ... More


Accurate Clock Pendulums

Robert J. Matthys

Published in print:
2004
Published Online:
January 2010
ISBN:
9780198529712
eISBN:
9780191712791
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198529712.001.0001
Subject:
Physics, History of Physics

The Shortt clock, made in the 1920s, is the most famous accurate clock pendulum ever known, having an accuracy of one second per year when kept at nearly constant temperature. Almost all of a ... More


Basis of the Nerve Impulse

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0004
Subject:
Psychology, Cognitive Neuroscience

The rapid conduction of signals by neurons over distances greater than about 1 mm occurs almost exclusively by electrical impulses. This chapter presents the fundamental concepts that underlie the ... More


Synaptic ‘Noise’: Experiments, Computational Consequences and Methods to Analyse Experimental Data

Alain Destexhe and Michelle Rudolph-Lilith

in Stochastic Methods in Neuroscience

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199235070
eISBN:
9780191715778
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199235070.003.0009
Subject:
Mathematics, Biostatistics

In the cerebral cortex of awake animals, neurons are subject to tremendous fluctuating activity, mostly of synaptic origin, termed “synaptic noise”. Synaptic noise is the dominant source of membrane ... More


Patch-Clamp Recording

W. Otto Friesen and Jonathon A. Friesen

in NeuroDynamix II: Concepts of Neurophysiology Illustrated by Computer Simulations

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195371833
eISBN:
9780199865178
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195371833.003.0002
Subject:
Psychology, Cognitive Neuroscience

Invented by Bert Sakmann and Erwin Neher during the 1970s, the patch-clamp recording technique aids scientists in examining the functions of individual protein molecules that form ion channels in ... More


Voltage-clamp studies in axons: Macroscopic and single-channel currents

WERNER VOGEL and JÜRGEN R. SCHWARZ

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0013
Subject:
Neuroscience, Disorders of the Nervous System

This chapter describes macroscopic membrane currents measured in amphibian and mammalian nodes of Ranvier with the voltage-clamp method. These results are compared with those of single-channel ... More


Electrophysiological techniques

Jean Mironneau

in Current Methods in Muscle Physiology: Advantages, Problems and Limitations

Published in print:
1998
Published Online:
March 2012
ISBN:
9780198523970
eISBN:
9780191724480
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523970.003.0013
Subject:
Neuroscience, Techniques

This chapter focuses on various electrophysiological techniques. The voltage-clamp technique has been a powerful tool in the development of membrane biophysics. Applied to large cells, such as squid ... More


Galvani’s Spark: The Story of the Nerve Impulse

Alan McComas

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.001.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

The nerve impulse is the basis of all human thoughts and emotions, and of all sensations and movements. As such, it has been the subject of scientific enquiry for more than two centuries, beginning ... More


John Wilson Moore

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0011
Subject:
Neuroscience, History of Neuroscience

John Moore initially became known for elucidating the action of tetrodotoxin and other neurotoxins using his innovative sucrose gap method for voltage clamping squid axon. He also was a pioneer in ... More


Introduction

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Nerve impulses traversing the brain were likened by Sherrington to points of light in an enchanted loom. The electrochemical nature of the nerve impulse was largely elucidated by Hodgkin and Huxley ... More


The Voltage Clamp

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0015
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Now in Chicago, Kenneth Cole employs a negative feedback circuit, devised by a colleague, to clamp the voltage across the membrane of the squid giant axon. He shows that during the action potential ... More


The Single Ion Channel

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0019
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

A “gating” current, predicted by the Hodgkin-Huxley equations twenty years earlier, is finally detected in the squid giant axon. Soon after, Bert Sakmann and Erwin Neher develop a patch clamp method ... More


Solid one-piece suspension springs

Robert James Matthys

in Accurate Clock Pendulums

Published in print:
2004
Published Online:
January 2010
ISBN:
9780198529712
eISBN:
9780191712791
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198529712.003.0018
Subject:
Physics, History of Physics

This chapter discusses how to make solid one-piece type of pendulum suspension springs. There are three types of pendulum suspension springs: the mechanically clamped type, the soldered assembly ... More


Fasteners for quartz pendulum rods

Robert James Matthys

in Accurate Clock Pendulums

Published in print:
2004
Published Online:
January 2010
ISBN:
9780198529712
eISBN:
9780191712791
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198529712.003.0025
Subject:
Physics, History of Physics

This chapter describes five different ways of fastening things to a quartz pendulum rod. To connect to a metal rod, a hole is drilled in it or a thread is cut on it. But how do you fasten something ... More


Control of the spatial distribution of sodium channels in the squid giant axon and its cell bodies

W. F. Gilly, M. T. Lucero, M. Perri, and J. Rosenthal

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0116
Subject:
Neuroscience, Invertebrate Neurobiology

This chapter summarizes the progress in developing a model system for studying the control of neuronal Na channel distribution based on the squid giant axon and its cell bodies located in the giant ... More


Electrophysiology of squid Schwann cells

N. Joan Abbott, E. R. Brown, Y. Pichon, and Fumio Kukita

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0133
Subject:
Neuroscience, Invertebrate Neurobiology

Schwann cells are the class of glial cells of the peripheral nervous system associated with axons. The myelin-forming Schwann cells of large-diameter vertebrate axons have a clear physiological ... More


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