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Markov Chain Models of Ion Channels and Calcium Release Sites

Jeffrey R. Groff, Hilary DeRemigio, and Gregory D. Smith

in Stochastic Methods in Neuroscience

Published in print:
2009
Published Online:
February 2010
ISBN:
9780199235070
eISBN:
9780191715778
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199235070.003.0002
Subject:
Mathematics, Biostatistics

This chapter is an introduction to modelling stochastically gating ion channels using continuous-time discrete-state Markov chains. Analytical and numerical methods are presented for determining ... More


The Axon: Structure, Function and Pathophysiology

Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys (eds)

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.001.0001
Subject:
Neuroscience, Disorders of the Nervous System

The axon, which is interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information ... More


Synapse-to-nucleus calcium signalling

Giles E. Hardingham

in Molecular Biology of the Neuron

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198509981
eISBN:
9780191723810
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509981.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

Many extracellular stimuli result in an elevation of intracellular calcium concentration. Calcium ions act as messengers, coupling many external events or stimuli to the cell's responses to those ... More


Neuromuscular transmission

Daniel Kernell

in The Motoneurone and its Muscle Fibres

Published in print:
2006
Published Online:
September 2009
ISBN:
9780198526551
eISBN:
9780191723896
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198526551.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

The connection between motoneuronal axons and skeletal muscle fibres (neuromuscular junction, NMJ) shares basic characteristics with many excitatory chemical synapses inside the central nervous ... More


Development of axons: Calcium, steering, and the growth cone

ROGER W. DAVENPORT, STEPHEN R. BOLSOVER, and S. B. KATER

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0010
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines the control mechanisms underlying the establishment, modification, and repair of nervous systems as they reside at the level of the neuronal growth cone. It begins with a brief ... More


Intracellular Calcium Control Mechanisms in Glia

Maria Luisa Cotrina and Maiken Nedergaard

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0017
Subject:
Neuroscience, Development, Disorders of the Nervous System

Glial cells rely on calcium ions to display a large variety of signaling capabilities inside the cell and among neighboring cells. These calcium activities are key to regulating not only the growth ... More


Voltage-Activated Ion Channels in Glial Cells

Michelle L. Olsen and Harald W. Sontheimer

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0009
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter discusses voltage-activated ion channels in glial cells, including sodium channels, calcium channels, and potassium channels. Studies have proven that glial cells contain a large variety ... More


Spine calcium signaling

Adam Carter and Bernardo Sabatini

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0011
Subject:
Neuroscience, Molecular and Cellular Systems

Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the local machinery necessary to ... More


Modeling Intracellular Calcium Dynamics

Erik De Schutter

in Computational Modeling Methods for Neuroscientists

Published in print:
2009
Published Online:
August 2013
ISBN:
9780262013277
eISBN:
9780262258722
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262013277.003.0005
Subject:
Neuroscience, Techniques

This chapter tries to model calcium dynamics inside neurons, and analyzes the cytoplasmic calcium concentration Ci to keep the extracellular concentration Co constant. It describes how to model the ... More


Tinnitus and aging

Jos J. Eggermont

in The Neuroscience of Tinnitus

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199605606
eISBN:
9780191741555
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199605606.003.0010
Subject:
Neuroscience, Sensory and Motor Systems, Development

Tinnitus prevalence increases with age. However, a comparison between findings following noise-induced hearing loss and age-related hearing loss suggests that aging may only play a minimal role in ... More


The Science of a Grilled Cheese Sandwich

Jennifer Kimmel

in The Kitchen as Laboratory: Reflections on the Science of Food and Cooking

Published in print:
2013
Published Online:
November 2015
ISBN:
9780231153454
eISBN:
9780231526920
Item type:
chapter
Publisher:
Columbia University Press
DOI:
10.7312/columbia/9780231153454.003.0002
Subject:
Sociology, Science, Technology and Environment

This chapter explains why certain varieties of cheese make better grilled cheese sandwiches. Melt is the ideal cheese characteristic needed to make a grilled cheese sandwich. Some cheeses melt better ... More


The patient presenting with frequently recurring urinary tract calculi

Hans-Göran Tiselius

in Supportive Care for the Urology Patient

Published in print:
2005
Published Online:
November 2011
ISBN:
9780198529415
eISBN:
9780191730344
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198529415.003.0025
Subject:
Palliative Care, Patient Care and End-of-Life Decision Making, Pain Management and Palliative Pharmacology

Patients with frequently recurring urinary stones have benefited over the last few decades from the many technological advances that have been made to facilitate the acute management of a symptomatic ... More


Selective Neuronal Vulnerability in the Hippocampus: Relationship to Neurological Diseases and Mechanisms for Differential Sensitivity of Neurons to Stress

Elias K. Michaelis

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0004
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

The phenomenon of selective neuronal vulnerability to neurological diseases or insults, such as ischemia-reperfusion, brain trauma, and ageing-associated neurodegeneration, was described in the ... More


Colorectal Cancer

John D. Potter and David Hunter

in Textbook of Cancer Epidemiology

Published in print:
2008
Published Online:
September 2009
ISBN:
9780195311174
eISBN:
9780199865093
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311174.003.0011
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

There is substantial evidence that colorectal cancer is, after lung cancer, one of the most preventable of the common cancers. Increased BMI among men along with a sedentary lifestyle among both ... More


Multiple calcium signalling pathways in squid giant presynaptic terminals

George J. Augustine, Joachim Deitmer, Michael Hans, Dieter Swandulla, and Karl Zipser

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0182
Subject:
Neuroscience, Invertebrate Neurobiology

This chapter considers the recent studies that use the fluorescent Ca2+ indicator, fura-2, to further characterize presynaptic Ca2+ signaling. The fluorescent Ca indicator, fura-2, can be used to ... More


Biochemical compartmentalization in dendrites

Fritjof Helmchen

in Dendrites

Published in print:
2007
Published Online:
March 2012
ISBN:
9780198566564
eISBN:
9780191724206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198566564.003.0010
Subject:
Neuroscience, Molecular and Cellular Systems

Dendrites have both electrical and biochemical characters, which are closely linked. This chapter discusses dendrites as compartments for chemical signals such as concentration changes of ions or ... More


Neuroprotection

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

in Brain Damage, Brain Repair

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198523376
eISBN:
9780191724534
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523376.003.0007
Subject:
Neuroscience, Techniques

Excitoxic damage, metabolic imbalance, oxidative stress, and calcium influx are each capable of inducing cell death by both necrotic and apoptotic mechanisms. If these various mechanisms contribute, ... More


The Greening of the Bluegrass

Maryjean Wall

in How Kentucky Became Southern: A Tale of Outlaws, Horse Thieves, Gamblers, and Breeders

Published in print:
2010
Published Online:
September 2011
ISBN:
9780813126050
eISBN:
9780813135410
Item type:
chapter
Publisher:
University Press of Kentucky
DOI:
10.5810/kentucky/9780813126050.003.0003
Subject:
History, American History: early to 18th Century

The composition of limestone, which is calcium carbonate, is very important to horse breeders because it includes a heavy concentration of phosphate, which plays a greater role in growing a strong ... More


Multilevel Modeling in Systems Biology: From Cells to Whole Organs

Denis Noble

in System Modeling in Cellular Biology: From Concepts to Nuts and Bolts

Published in print:
2006
Published Online:
August 2013
ISBN:
9780262195485
eISBN:
9780262257060
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262195485.003.0014
Subject:
Mathematics, Mathematical Biology

This chapter discusses the philosophy of multilevel modeling and illustrates this development in the case of the heart. It covers cellular models of the heart; connecting to ion pumps and calcium ... More


Self-Regulation of Ocean Composition by the Biosphere

Lee R. Kump

in Scientists Debate Gaia: The Next Century

Published in print:
2004
Published Online:
August 2013
ISBN:
9780262194983
eISBN:
9780262283182
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262194983.003.0010
Subject:
Environmental Science, Climate

This chapter explores the host of mechanisms involving biological and physical processes in the context of the evolution of ocean chemistry on geologic time scales. Large fluctuations in the salinity ... More


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