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Computational Psychiatry: New Perspectives on Mental Illness

A. David Redish and Joshua A. Gordon (eds)

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
book
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.001.0001
Subject:
Psychology, Cognitive Neuroscience

Psychiatry is at a crossroads. Faced with challenges of diagnosis and treatment, it must balance analyses at both neurological and psychological levels. Issues of comorbidity, treatment stability, ... More


From Psychiatry to Computation and Back Again

A. David Redish and Joshua A. Gordon

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0017
Subject:
Psychology, Cognitive Neuroscience

In the opening chapters of this volume, we outlined a series of challenges facing psychiatry, as well as a description of its various promises, and suggested that taking a computational perspective ... More


Breakdowns and Failure Modes: An Engineer’s View

A. David Redish and Joshua A. Gordon

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0002
Subject:
Psychology, Cognitive Neuroscience

Psychiatry faces a number of challenges due largely to the complexity of the relationship between mind and brain. Starting from the now well-justified assumption that the mind is instantiated in the ... More


A Novel Framework for Improving Psychiatric Diagnostic Nosology

Shelly B. Flagel, Daniel S. Pine, Susanne E. Ahmari, Michael B. First, Karl J. Friston, Christoph Mathys, A. David Redish, Katharina Schmack, Jordan W. Smoller, and Anita Thapar

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0010
Subject:
Psychology, Cognitive Neuroscience

This chapter proposes a new framework for diagnostic nosology based on Bayesian principles. This novel integrative framework builds upon and improves the current diagnostic system in psychiatry. ... More


Complexity and Heterogeneity in Psychiatric Disorders: Opportunities for Computational Psychiatry

Nelson Totah, Huda Akil, Quentin J. M. Huys, John H. Krystal, Angus W. MacDonald, Tiago V. Maia, Robert C. Malenka, and Wolfgang M. Pauli

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0003
Subject:
Psychology, Cognitive Neuroscience

Psychiatry faces numerous challenges: the reconceptualization of symptoms and diagnoses, disease prevention, treatment development and monitoring of its effects, and the provision of individualized, ... More


Candidate Examples for a Computational Approach to Address Practical Problems in Psychiatry

Rosalyn Moran, Klaas Enno Stephan, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Peter W. Kalivas, P. Read Montague, Martin P. Paulus, and Frederike Petzschner

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0012
Subject:
Psychology, Cognitive Neuroscience

Scientists and clinicians can utilize a model-based framework to develop computational approaches to psychiatric practice and bring scientific discoveries to a clinical interface. This chapter ... More


Computational Nosology and Precision Psychiatry: A Proof of Concept

Karl J. Friston

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0011
Subject:
Psychology, Cognitive Neuroscience

This chapter provides an illustrative treatment of psychiatric morbidity that offers an alternative to the standard nosological model in psychiatry. It considers what would happen if we treated ... More


On the Cusp: Current Challenges and Promises in Psychiatry

Joshua A. Gordon and A. David Redish

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0001
Subject:
Psychology, Cognitive Neuroscience

Modern psychiatry seeks to treat disorders of the brain, the most complex and least understood organ in the human body. This complexity poses a set of challenges that make progress in psychiatric ... More


What Does Computational Psychiatry Need to Explain to Capture Mechanisms of Psychopathology?: Facts, Almost Facts, and Hints

Deanna M. Barch

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0004
Subject:
Psychology, Cognitive Neuroscience

This chapter provides specific research examples on the neurobiology of mental illness—using psychosis as a case in point—that may begin to rise to the level of “facts,” or at least “almost facts” or ... More


Computational Approaches for Studying Mechanisms of Psychiatric Disorders

Zeb Kurth-Nelson, John P. O’Doherty, Deanna M. Barch, Sophie Denève, Daniel Durstewitz, Michael J. Frank, Joshua A. Gordon, Sanjay J. Mathew, Yael Niv, Kerry Ressler, and Heike Tost

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0005
Subject:
Psychology, Cognitive Neuroscience

Vast spectra of biological and psychological processes are potentially involved in the mechanisms of psychiatric illness. Computational neuroscience brings a diverse toolkit to bear on understanding ... More


Computational Cognitive Neuroscience Approaches to Deconstructing Mental Function and Dysfunction

Michael J. Frank

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0006
Subject:
Psychology, Cognitive Neuroscience

Advances in our understanding of brain function and dysfunction require the integration of heterogeneous sources of data across multiple levels of analysis, from biophysics to cognition and back. ... More


How Could We Get Nosology from Computation?

Christoph Mathys

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0007
Subject:
Psychology, Cognitive Neuroscience

Psychiatry has found it difficult to develop a nosology that allows for the targeted treatment of disorders of the mind. This article sets out a possible way forward: harnessing systems theory to ... More


Current State of Psychiatric Nosology

Michael B. First

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0008
Subject:
Psychology, Cognitive Neuroscience

Psychiatric classifications categorize how patients present to mental health care professionals and are necessarily utilitarian. From the clinician’s perspective, the most important goal of a ... More


The Computation of Collapse: Can Reliability Engineering Shed Light on Mental Illness?

Angus W. MacDonald, Jennifer L. Zick, Theoden I. Netoff, and Matthew V. Chafee

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0009
Subject:
Psychology, Cognitive Neuroscience

Computational modeling in psychiatry has generally followed from efforts to understand cognitive processes (McClelland and Rumelhart 1986) or the nervous system (Hodgkin and Huxley 1952). This stands ... More


There Are No Killer Apps but Connecting Neural Activity to Behavior through Computation Is Still a Good Idea

P. Read Montague

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0013
Subject:
Psychology, Cognitive Neuroscience

The quest to understand the relationship between neural activity and behavior has been ongoing for well over a hundred years. Although research based on the stimulus-and-response approach to ... More


Call for Pragmatic Computational Psychiatry: Integrating Computational Approaches and Risk-Prediction Models and Disposing of Causality

Martin P. Paulus, Crane Huang, and Katia M. Harlé

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0014
Subject:
Psychology, Cognitive Neuroscience

Biological psychiatry is at an impasse. Despite several decades of intense research, few, if any, biological parameters have contributed to a significant improvement in the life of a psychiatric ... More


A Valuation Framework for Emotions Applied to Depression and Recurrence

Quentin J. M. Huys

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0015
Subject:
Psychology, Cognitive Neuroscience

The burden of depression is substantially aggravated by relapses and recurrences, and these become more inevitable with every episode of depression. This chapter describes how computational ... More


Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience

John H. Krystal, Alan Anticevic, John D. Murray, David Glahn, Naomi Driesen, Genevieve Yang, and Xiao-Jing Wang

in Computational Psychiatry: New Perspectives on Mental Illness

Published in print:
2016
Published Online:
May 2017
ISBN:
9780262035422
eISBN:
9780262337854
Item type:
chapter
Publisher:
The MIT Press
DOI:
10.7551/mitpress/9780262035422.003.0016
Subject:
Psychology, Cognitive Neuroscience

Clinical heterogeneity presents important challenges to optimizing psychiatric diagnoses and treatments. Patients clustered within current diagnostic schema vary widely on many features of their ... More


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