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Obituary

David J Weiss and James Shanteau

in A Science of Decision Making: The Legacy of Ward Edwards

Published in print:
2008
Published Online:
January 2009
ISBN:
9780195322989
eISBN:
9780199869206
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195322989.003.0039
Subject:
Psychology, Cognitive Psychology

Following on from the previous two chapters presents an obituary for Ward Edwards. Ward's 1954 paper in the Psychological Bulletin introduced decision making as a research topic for psychologists. He ... More


Bioethics and the Brain

Walter Glannon

Published in print:
2006
Published Online:
January 2007
ISBN:
9780195307788
eISBN:
9780199867431
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195307788.001.0001
Subject:
Philosophy, Moral Philosophy

Our ability to map and intervene in the structure of the human brain is proceeding at a very quick rate. Advances in psychiatry, neurology, and neurosurgery have given us fresh insights into the ... More


Cortical Oscillations in Health and Disease

Roger Traub, MD and Miles Whittington, PhD

Published in print:
2010
Published Online:
May 2010
ISBN:
9780195342796
eISBN:
9780199776276
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195342796.001.0001
Subject:
Neuroscience, Molecular and Cellular Systems, Development

This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ... More


Creating Modern Neuroscience: The Revolutionary 1950s

Gordon M. Shepherd MD, DPhil

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195391503
eISBN:
9780199863464
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195391503.001.0001
Subject:
Neuroscience, History of Neuroscience

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, ... More


Dopamine and Motor Function in Rat and Mouse Models of Parkinson’s Disease

Timothy Schallert and Sheila M. Fleming

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0019
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

In Parkinson's disease (PD), dopamine (DA) neurons in the substantia nigra pars compacta (SNc) progressively degenerate. This disruption in nigrostriatal DA transmission results in many motor ... More


Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson’s Disease

D. James Surmeier, Michelle Day, Tracy S. Gertler, C. Savio Chan, and Weixing Shen

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0025
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Dopamine (DA) has long been known to be a critical modulator of striatal processing of cortical and thalamic signals carried by glutamatergic synapses on the principal neurons of the striatum—medium ... More


Exploring the Myths about Parkinson’s Disease

Yves Agid and Andreas Hartmann

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0029
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter addresses nine myths about Parkinson's disease (PD). Among these are the myths that PD is a movement disorder characterized by the classic triad of akinesia, rigidity, and tremor; that ... More


Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease

M. Angela Cenci

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0030
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter begins with a discussion of motor complications of L-DOPA pharmacotherapy. It then discusses animal models of treatment-induced motor complications and the multilayered pathophysiology ... More


Progression of Parkinson’s Disease Revealed by Imaging Studies

David J. Brooks

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0031
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter discusses imaging studies of Parkinson's disease (PD). Imaging dopaminergic function with positron emission tomography (PET) and single photon computed emission tomography (SPECT) or ... More


Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in Rodent Models of Parkinson's Disease

Stephen B. Dunnett and Anders Björklund

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0032
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter reviews the transplantation of dopamine (DA) neurons as a powerful model for understanding the basic neurobiology and methods for achieving viable cell transplantation in the brain. ... More


Clinical Experiences with Dopamine Neuron Replacement in Parkinson’s Disease: What Is the Future?

Olle Lindvall

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0033
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Cell therapy research in Parkinson's disease (PD) seeks to develop this approach into a clinically competitive treatment. It should be emphasized, though, that during the more than 20 years since the ... More


Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson’s Disease

Deniz Kirik, Tomas Björklund, Shilpa Ramaswamy, and Jeffrey H. Kordower

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0034
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

Novel therapeutic intervention based on gene therapy has moved the field of Parkinson's disease (PD) research forward during the last decade. The process of supplementing cells with genes that ... More


Neuroprotective Strategies in Parkinson’s Disease

C. Warren Olanow

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0035
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter focuses on neuroprotective therapies for Parkinson's disease (PD). PD patients inevitably develop disability despite currently available medical and surgical therapies. Accordingly, a ... More


Functional Neuroanatomy of Dopamine in the Striatum

Charles R. Gerfen

in Dopamine Handbook

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195373035
eISBN:
9780199865543
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195373035.003.0002
Subject:
Neuroscience, Molecular and Cellular Systems, History of Neuroscience

This chapter begins with a discussion of the mesostriatal dopamine system. It then covers striatal patch-matrix compartments, input—output organization of the striatal patch and matrix compartments, ... More


Diseases of the nervous system

Fabrizio Benedetti

in Placebo Effects: Understanding the mechanisms in health and disease

Published in print:
2008
Published Online:
September 2009
ISBN:
9780199559121
eISBN:
9780191724022
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559121.003.0004
Subject:
Neuroscience, Molecular and Cellular Systems

Besides pain, Parkinson's disease represents an excellent model to study the neurobiological mechanisms of the placebo effect. The placebo effect in Parkinson's disease is mediated by dopamine ... More


Structural Abnormalities in Parkinson’s Disease: MRI and Related Methods

Kathrin Reetz and Ferdinand Binkofski

in Imaging in Parkinson’s Disease

Published in print:
2011
Published Online:
September 2011
ISBN:
9780195393484
eISBN:
9780199914494
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195393484.003.0027
Subject:
Neuroscience, Disorders of the Nervous System, Techniques

The traditional role of MRI in parkinsonism is to exclude secondary causes of symptoms. Recent advances in MR methodology, including voxel-based morphometry, diffusion imaging, and inversion recovery ... More


Neurobehavioral Consequences of Neurosurgical Treatments and Focal Lesions of Frontal–Subcortical Circuits

Jean A. Saint-Cyr, Yuri L. Bronstein, and Jeffrey L. Cummings

in Principles of Frontal Lobe Function

Published in print:
2002
Published Online:
May 2009
ISBN:
9780195134971
eISBN:
9780199864157
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195134971.003.0026
Subject:
Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems

This chapter describes the neuroanatomy and neurotransmitters of frontal-subcortical circuits and the clinical behavioral syndromes associated with the specific focal lesions within the circuits. It ... More


Glutamate and Glutamate Receptors in Neurological Diseases

ROBERT BALÁZS, RICHARD J. BRIDGES, and CARL W. COTMAN

in Excitatory Amino Acid Transmission in Health and Disease

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195150025
eISBN:
9780199865079
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195150025.003.0012
Subject:
Neuroscience, Sensory and Motor Systems

Although glutamate (Glu) normally functions as a neurotransmitter, excess Glu can be harmful and can cause cells to degenerate. Glutamate can cause neuronal cell death by a mechanism referred to as ... More


Sex Differences in Parkinson’s Disease

David G. Standaert and Ippolita Cantuti-Castelvetri

in Sex Differences in the Brain: From Genes to Behavior

Published in print:
2007
Published Online:
January 2010
ISBN:
9780195311587
eISBN:
9780199865048
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195311587.003.0023
Subject:
Neuroscience, Molecular and Cellular Systems

Parkinson's disease (PD) is a slow progressing neurodegenerative disease affecting up to 3% of the population over the age of 65 years, amounting to more than 500,000 individuals in the United ... More


Jean-Martin Charcot: Clinical Neurology Comes of Age

Stanley Finger

in Minds Behind the Brain: A history of the pioneers and their discoveries

Published in print:
2005
Published Online:
January 2010
ISBN:
9780195181821
eISBN:
9780199865277
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195181821.003.0012
Subject:
Neuroscience, History of Neuroscience

During the first half of the 19th century, most neurological diseases were categorized on the basis of a single feature, such as a paralysis or a tremor. Labeling and classifying neurological ... More


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