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Antibody Engineering: A Renaissance for Mab Therapeutics

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0008
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the emergence of engineered monoclonal antibodies (Mabs) in the 1990s. The failure of Centoxin to gain FDA approval prompted many in the biotechnology and pharmaceutical ... More


The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Lara V Marks

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
book
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.001.0001
Subject:
History, History of Science, Technology, and Medicine

This book tells the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are ... More


Hunting for the Elusive “Magic Bullet”

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0001
Subject:
History, History of Science, Technology, and Medicine

This chapter traces the history of the discovery of antibodies, from the late nineteenth-century theories of immunity to the development of monoclonal antibodies (Mabs) in 1975—a breakthrough that ... More


A Hesitant Start: Patents, Politics, and Process

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0002
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses how the dissemination of monoclonal antibodies (Mabs) involved complex negotiations between actors in numerous scientific laboratories across the world, negotiations that also ... More


Breakthroughs at the Bench

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0003
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses how monoclonal antibodies (Mabs) opened new frontiers in research well beyond immunology and transformed the way scientists analyzed biological phenomena in the early 1980s. ... More


The First Medical Applications

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0004
Subject:
History, History of Science, Technology, and Medicine

This chapter describes the early clinical applications of monoclonal antibodies (Mabs). The technology offered so many different possibilities that it was difficult to know where to start. Many of ... More


Joy, Disappointment, Determination: Early Clinical Tests

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0005
Subject:
History, History of Science, Technology, and Medicine

This chapter considers the development of monoclonal antibodies (Mabs) for cancer treatment. In the early 1980s, many scientists were optimistic that Mabs would defeat cancer. In 1982, John Minna of ... More


The Wild West of Antibody Commercialization

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0006
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the pioneers who commercialized monoclonal antibodies (Mabs) from the late 1970s. Those who did so were entering totally uncharted territory. Not only was the technique still ... More


The Challenge of Monoclonal Antibody Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0007
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses the efforts to develop monoclonal antibody (Mab) therapeutics. The quick commercialization of Mab diagnostics prompted many to assume that Mab therapeutics would soon reach the ... More


Blockbuster Mab Drugs

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0009
Subject:
History, History of Science, Technology, and Medicine

This chapter explores the development of rituximab and infliximab, two of the best-selling monoclonal antibody (Mab) therapeutics today. The evolution of these drugs not only illustrates how a single ... More


A Quiet Revolution: The Legacy of Monoclonal Antibodies

Lara V. Marks

in The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

Published in print:
2015
Published Online:
January 2016
ISBN:
9780300167733
eISBN:
9780300213522
Item type:
chapter
Publisher:
Yale University Press
DOI:
10.12987/yale/9780300167733.003.0010
Subject:
History, History of Science, Technology, and Medicine

This chapter discusses legacy of monoclonal antibodies (Mabs). Mab therapeutics are some of the best-selling drugs in the world today. As of 2012 there were over thirty Mab drugs on the world market. ... More


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