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The Early Detection of Alzheimer's Disease with Positron Emission Tomography

Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan De Santi, Yi Li, Lidia Glodzik, Miroslaw Brys, Wai Tsui, Henry Rusinek, and Mony J. de Leon

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0011
Subject:
Neuroscience, Techniques, Development

Reductions in the cerebral metabolic rate of glucose (CMRglc), a measure of neuronal function, have proven to be a promising tool in the early diagnosis of Alzheimer's disease (AD). FDG-PET imaging ... More


Hippocampus and Human Disease

Walker Matthew, Chan Dennis, and Thom Maria

in The Hippocampus Book

Published in print:
2006
Published Online:
May 2009
ISBN:
9780195100273
eISBN:
9780199864133
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195100273.003.0016
Subject:
Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience

This chapter focuses on two disorders in which the role of the hippocampus has been extensively investigated: Alzheimer's disease and temporal lobe epilepsy. Although in Alzheimer's disease the ... More


MRI as a Surrogate Marker in Clinical Trials in Alzheimer’s Disease

Frank Jessen and Harald Hampel

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0019
Subject:
Neuroscience, Techniques, Development

The rapid development of novel treatment targets for Alzheimer's disease (AD) requires tools to assess the effects of these treatments on disease progression. Structural neuroimaging with CCT and ... More


Alzheimer’s Disease and Vascular Dementia

Lorene M. Nelson, Caroline M. Tanner, Stephen K. Van Den Eeden, and Valerie M. McGuire

in Neuroepidemiology: From principles to practice

Published in print:
2004
Published Online:
September 2009
ISBN:
9780195133790
eISBN:
9780199863730
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195133790.003.05
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

This chapter explores the frequency with which dementing illnesses occur in populations, their distributions by personal characteristics, and what is known about their causes and potential protective ... More


Alzheimer’s Disease

Maija Pihlajamäki and Hilkka Soininen

in The Clinical Neurobiology of the Hippocampus: An integrative view

Published in print:
2012
Published Online:
September 2012
ISBN:
9780199592388
eISBN:
9780199949922
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199592388.003.0012
Subject:
Neuroscience, Disorders of the Nervous System, Behavioral Neuroscience

The clinical spectrum of hippocampal dysfunction encompasses a wide range of neuropsychiatric symptoms. The present chapter aims at addressing the hippocampal involvement in the most common form of ... More


Alzheimer's disease

Andrew J. Larner

in Cognitive Neurology: A clinical textbook

Published in print:
2008
Published Online:
March 2012
ISBN:
9780198569275
eISBN:
9780191724213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569275.003.0012
Subject:
Neuroscience, Techniques

The diagnosis of Alzheimer's disease (AD) may be possible, probable, or definite. In clinical practice, most diagnoses are of probable AD: dementia is established on the basis of clinical examination ... More


Differential Diagnosis of Dementia Using Functional Neuroimaging

Eric Salmon, Fabienne Collette, and Gaëtan Garraux

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0015
Subject:
Neuroscience, Techniques, Development

Functional neuroimaging in neurodegenerative dementias provides 3D representations of brain activity that are relatively characteristic of the underlying phenotypic distribution of cerebral lesions. ... More


MRI and the Differential Diagnosis of Dementia

António J. Bastos-Leite and Philip Scheltens

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0016
Subject:
Neuroscience, Techniques, Development

Magnetic resonance imaging (MRI) has opened up the way to diagnose dementia in vivo. It provides clear evidence for hippocampal atrophy in Alzheimer's disease (AD), lobar atrophy in frontotemporal ... More


Mental Status Testing

Ian McDowell

in Measuring Health: A guide to rating scales and questionnaires

Published in print:
2006
Published Online:
September 2009
ISBN:
9780195165678
eISBN:
9780199864034
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195165678.003.0008
Subject:
Public Health and Epidemiology, Public Health, Epidemiology

Population aging has highlighted the importance of disorders of cognition such as Alzheimer's disease. This chapter outlines a range of approaches to assessing cognitive ability and reviews thirteen ... More


The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Robert Veerhuis, Jeroen J.M. Hoozemans, Annachiara Cagnin, Piet Eikelenboom, and Richard B. Banati

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0045
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter focuses on the contribution of activated microglia to the progression of Alzheimer's disease (AD) at various stages of the pathological cascade. Clusters of activated microglia occur ... More


The neuropsychological presentation of Alzheimer’s disease and other neurodegenerative disorders

Julie Snowden

in The Handbook of Clinical Neuropsychology

Published in print:
2010
Published Online:
September 2010
ISBN:
9780199234110
eISBN:
9780191594250
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199234110.003.028
Subject:
Psychology, Neuropsychology, Clinical Psychology

Alzheimer's disease and other neurodegenerative diseases that lead to progressive cognitive impairment are conventionally classified as ‘the dementias’. Dementia is traditionally defined as a ... More


White Matter Hyperintensities in Aging and Dementia

Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0017
Subject:
Neuroscience, Techniques, Development

Both advancing age and cognitive impairment are associated with increased prevalence of various brain diseases, with Alzheimer's disease (AD) and cerebrovascular disease (CVD) being the most common. ... More


Ethical dilemmas in neurodegenerative disease: respecting patients at the twilight of agency

Agnieszka Jaworska

in Neuroethics: Defining the issues in theory, practice, and policy

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198567219
eISBN:
9780191724084
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198567219.003.0007
Subject:
Neuroscience, Behavioral Neuroscience

This chapter presents a case study that illustrates the interplay between ethical conceptual analysis and neuroscientific findings in the resolution of moral dilemmas that arise in Alzheimer's ... More


Alzheimer’s Disease—is it Caused by Cerebrovascular Dysfunction?

Christian Humpel

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0015
Subject:
Neuroscience, Molecular and Cellular Systems

Alzheimer's disease (AD) is a progressive chronic disorder characterized by β-amyloid plaques, tau pathology, cell death of cholinergic neurons, and inflammatory responses. The reasons for this ... More


Proteases In Β-Amyloid Metabolism: Potential Therapeutic Targets Against Alzheimer‘;S Disease

Noureddine Brakch and Mohamed Rholam

in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging

Published in print:
2009
Published Online:
January 2010
ISBN:
9780195326697
eISBN:
9780199864874
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195326697.003.0016
Subject:
Neuroscience, Molecular and Cellular Systems

Proteases are extremely important signaling molecules that are involved in numerous vital processes. Protease signaling pathways are strictly regulated, and therefore the dysregulation of their ... More


Genetics of dementia

William S. Brooks, Clement T. Loy, John B. J. Kwok, and Peter R. Schofield

in Cognitive Neurology: A clinical textbook

Published in print:
2008
Published Online:
March 2012
ISBN:
9780198569275
eISBN:
9780191724213
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198569275.003.0016
Subject:
Neuroscience, Techniques

The clinical syndrome of dementia can occur in a range of conditions. Some dementia causing diseases are clearly genetic in origin, such as Huntington's disease (HD) or familial Alzheimer's disease ... More


CNS immune reactions in Alzheimer’s disease: microglia mediated mechanisms of inflammation in the Alzheimer’s disease brain and their relevance to new therapuetic strategies

Joseph Rogers, Carl J. Kovelowski, and Ron Strohmeyer

in Immune and Inflammatory Responses in the Nervous System

Published in print:
2002
Published Online:
March 2012
ISBN:
9780198509806
eISBN:
9780191724596
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198509806.003.0010
Subject:
Neuroscience, Disorders of the Nervous System

This chapter examines the immune reactions of the central nervous system in Alzheimer's disease (AD), analysing the role of microglia in the mechanisms of inflammation in the AD brain and their ... More


Databasing the Aging Brain

John Darrell, Van Horn, and Arthur W. Toga

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0021
Subject:
Neuroscience, Techniques, Development

Large-scale archives of primary neuroimaging data of older populations are an essential element for contemporary research into normal and disease processes associated with aging. In this chapter, we ... More


Retention of Function in the Aged Brain:: The Pivotal Role of β-Amyloid

Carl W. Cotman and Aileen J. Anderson

in Brain and Memory: Modulation and Mediation of Neuroplasticity

Published in print:
1995
Published Online:
March 2012
ISBN:
9780195082944
eISBN:
9780199847877
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082944.003.0008
Subject:
Psychology, Cognitive Neuroscience

This chapter describes the basic deficits in learning and memory observed in Alzheimer's disease (AD), along with the functional disconnection of cortical-hippocampal circuitry associated with its ... More


Alzheimer’s disease, the parietal lobe, and topographical disorientation

Paul A. Dudchenko

in Why People Get Lost: The Psychology and Neuroscience of Spatial Cognition

Published in print:
2010
Published Online:
September 2010
ISBN:
9780199210862
eISBN:
9780191594199
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199210862.003.0009
Subject:
Psychology, Cognitive Neuroscience, Cognitive Psychology

This chapter considers spatial cognition in relation to three neurological conditions: Alzheimer's disease, parietal cortex dysfunction, and topographical disorientation. For Alzheimer's disease, one ... More


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