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Iris on Safari: A Personal Record

John Bayley

in Iris Murdoch, Philosopher

Published in print:
2011
Published Online:
September 2012
ISBN:
9780199289905
eISBN:
9780191728471
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199289905.003.0003
Subject:
Philosophy, History of Philosophy, Moral Philosophy

This chapter presents a short memoir of Iris Murdoch as lecturer and traveller—and her relations, among other things, to God, to power (and Elias Canetti), and to what Philippa Foot has called ... More


The Alzheimer Conundrum: Entanglements of Dementia and Aging

Margaret Lock

Published in print:
2013
Published Online:
October 2017
ISBN:
9780691149783
eISBN:
9781400848461
Item type:
book
Publisher:
Princeton University Press
DOI:
10.23943/princeton/9780691149783.001.0001
Subject:
Anthropology, Social and Cultural Anthropology

Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no ... More


Memories, Magic, & a Major Addiction

Gary L. Wenk

in Your Brain on Food: How Chemicals Control Your Thoughts and Feelings

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195388541
eISBN:
9780199863587
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195388541.003.0002
Subject:
Neuroscience, Behavioral Neuroscience, Neuroendocrine and Autonomic

The actions of the neurotransmitter acetylcholine influence the function of many brain regions. Within these regions, acetylcholine allows you to learn and remember, to regulate your attention and ... More


Brain Enhancement and Other Magical Beliefs

Gary L. Wenk

in Your Brain on Food: How Chemicals Control Your Thoughts and Feelings

Published in print:
2010
Published Online:
September 2010
ISBN:
9780195388541
eISBN:
9780199863587
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195388541.003.0009
Subject:
Neuroscience, Behavioral Neuroscience, Neuroendocrine and Autonomic

No drugs or nutrients are currently available that can reverse the primary cause of cognitive decline: normal aging. Also, it is currently impossible to enhance the function of a normal brain. These ... More


The Early Detection of Alzheimer's Disease with Positron Emission Tomography

Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan De Santi, Yi Li, Lidia Glodzik, Miroslaw Brys, Wai Tsui, Henry Rusinek, and Mony J. de Leon

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0011
Subject:
Neuroscience, Techniques, Development

Reductions in the cerebral metabolic rate of glucose (CMRglc), a measure of neuronal function, have proven to be a promising tool in the early diagnosis of Alzheimer's disease (AD). FDG-PET imaging ... More


Differential Diagnosis of Dementia Using Functional Neuroimaging

Eric Salmon, Fabienne Collette, and Gaëtan Garraux

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0015
Subject:
Neuroscience, Techniques, Development

Functional neuroimaging in neurodegenerative dementias provides 3D representations of brain activity that are relatively characteristic of the underlying phenotypic distribution of cerebral lesions. ... More


MRI and the Differential Diagnosis of Dementia

António J. Bastos-Leite and Philip Scheltens

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0016
Subject:
Neuroscience, Techniques, Development

Magnetic resonance imaging (MRI) has opened up the way to diagnose dementia in vivo. It provides clear evidence for hippocampal atrophy in Alzheimer's disease (AD), lobar atrophy in frontotemporal ... More


White Matter Hyperintensities in Aging and Dementia

Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0017
Subject:
Neuroscience, Techniques, Development

Both advancing age and cognitive impairment are associated with increased prevalence of various brain diseases, with Alzheimer's disease (AD) and cerebrovascular disease (CVD) being the most common. ... More


MRI as a Surrogate Marker in Clinical Trials in Alzheimer’s Disease

Frank Jessen and Harald Hampel

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0019
Subject:
Neuroscience, Techniques, Development

The rapid development of novel treatment targets for Alzheimer's disease (AD) requires tools to assess the effects of these treatments on disease progression. Structural neuroimaging with CCT and ... More


Databasing the Aging Brain

John Darrell, Van Horn, and Arthur W. Toga

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0021
Subject:
Neuroscience, Techniques, Development

Large-scale archives of primary neuroimaging data of older populations are an essential element for contemporary research into normal and disease processes associated with aging. In this chapter, we ... More


Cognitive Reserve and Aging

Yaakov Stern

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0006
Subject:
Neuroscience, Techniques, Development

The concept of reserve has been proposed to account for the disjunction between the degree of brain damage and its clinical outcome. After reviewing epidemiologic data supporting the concept of ... More


Genetics and Imaging in Alzheimer’s Disease

Susan Y. Bookheimer

in Imaging the Aging Brain

Published in print:
2009
Published Online:
February 2010
ISBN:
9780195328875
eISBN:
9780199864836
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195328875.003.0009
Subject:
Neuroscience, Techniques, Development

The pathological changes that give rise to Alzheimer's disease (AD) begin years and potentially decades before disease onset. This is well demonstrated using a range of in vivo imaging tools ... More


New Frontiers in Cognitive Aging

Roger Dixon, Lars Backman, and Lars-Goran Nilsson (eds)

Published in print:
2004
Published Online:
March 2012
ISBN:
9780198525691
eISBN:
9780191689369
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198525691.001.0001
Subject:
Psychology, Cognitive Psychology

With an ever increasing population of aging people in the western world, it is more crucial than ever that we try to understand how and why cognitive competence breaks down with advancing age; why do ... More


Mental and behavioural disorders

Fabrizio Benedetti

in Placebo Effects: Understanding the mechanisms in health and disease

Published in print:
2008
Published Online:
September 2009
ISBN:
9780199559121
eISBN:
9780191724022
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199559121.003.0005
Subject:
Neuroscience, Molecular and Cellular Systems

In depression, a fluoxetine treatment and a placebo treatment affect similar brain regions. In addition, covert (unexpected) administration of anti-anxiety drugs is less effective than overt ... More


Living with Alzheimer's: Managing Memory Loss, Identity, and Illness

Renée L. Beard

Published in print:
2016
Published Online:
January 2017
ISBN:
9781479800117
eISBN:
9781479855377
Item type:
book
Publisher:
NYU Press
DOI:
10.18574/nyu/9781479800117.001.0001
Subject:
Social Work, Health and Mental Health

Alzheimer’s is ubiquitous. Stories of the heart-wrenching drudgery of care giving, escalating incidence rates, and the new path to a cure just around the corner are everywhere. Yet we rarely see or ... More


Number in electron microscopy: estimation of total number of synapses in the main regions of human neocortex

Jens R. Nyengaard, Karl-Anton Dorph-Petersen, and Yong Tang

in Quantitative Methods in Neuroscience: A Neuroanatomical Approach

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198505280
eISBN:
9780191723766
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198505280.003.0006
Subject:
Neuroscience, Techniques

Significant disagreements exist among previous morphometric studies of synapse number in relation to memory deficits associated with aging and diseases such as Alzheimer's disease. There may be a ... More


Neuroglia

Helmut Kettenmann and Bruce R. Ransom (eds)

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.001.0001
Subject:
Neuroscience, Development, Disorders of the Nervous System

This book details the basic biology and function of glial cells. It covers the entire field of glial research from the basic molecular and cellular properties of these cells to their involvement in ... More


Memory of Places and Spaces and the Design of Facilities for the Aging

John Paul Eberhard

in Brain Landscape: The Coexistence of Neuroscience and Architecture

Published in print:
2009
Published Online:
May 2009
ISBN:
9780195331721
eISBN:
9780199864058
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195331721.003.0005
Subject:
Neuroscience, Behavioral Neuroscience, Techniques

This chapter discusses the relationship between how memory helps to form the experiences we have of places and spaces. This includes special considerations in designing facilities for the aging ... More


Ethical dilemmas in neurodegenerative disease: respecting patients at the twilight of agency

Agnieszka Jaworska

in Neuroethics: Defining the issues in theory, practice, and policy

Published in print:
2004
Published Online:
September 2009
ISBN:
9780198567219
eISBN:
9780191724084
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198567219.003.0007
Subject:
Neuroscience, Behavioral Neuroscience

This chapter presents a case study that illustrates the interplay between ethical conceptual analysis and neuroscientific findings in the resolution of moral dilemmas that arise in Alzheimer's ... More


The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Robert Veerhuis, Jeroen J.M. Hoozemans, Annachiara Cagnin, Piet Eikelenboom, and Richard B. Banati

in Neuroglia

Published in print:
2004
Published Online:
May 2009
ISBN:
9780195152227
eISBN:
9780199865024
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195152227.003.0045
Subject:
Neuroscience, Development, Disorders of the Nervous System

This chapter focuses on the contribution of activated microglia to the progression of Alzheimer's disease (AD) at various stages of the pathological cascade. Clusters of activated microglia occur ... More


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