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Voltage-clamp studies in axons: Macroscopic and single-channel currents

WERNER VOGEL and JÜRGEN R. SCHWARZ

in The Axon: Structure, Function and Pathophysiology

Published in print:
1995
Published Online:
May 2009
ISBN:
9780195082937
eISBN:
9780199865802
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195082937.003.0013
Subject:
Neuroscience, Disorders of the Nervous System

This chapter describes macroscopic membrane currents measured in amphibian and mammalian nodes of Ranvier with the voltage-clamp method. These results are compared with those of single-channel ... More


Electrophysiological techniques

Jean Mironneau

in Current Methods in Muscle Physiology: Advantages, Problems and Limitations

Published in print:
1998
Published Online:
March 2012
ISBN:
9780198523970
eISBN:
9780191724480
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198523970.003.0013
Subject:
Neuroscience, Techniques

This chapter focuses on various electrophysiological techniques. The voltage-clamp technique has been a powerful tool in the development of membrane biophysics. Applied to large cells, such as squid ... More


Galvani’s Spark: The Story of the Nerve Impulse

Alan McComas

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
book
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.001.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

The nerve impulse is the basis of all human thoughts and emotions, and of all sensations and movements. As such, it has been the subject of scientific enquiry for more than two centuries, beginning ... More


John Wilson Moore

Larry R. Squire

in The History of Neuroscience in Autobiography: Volume 7

Published in print:
2011
Published Online:
January 2012
ISBN:
9780195396133
eISBN:
9780199918409
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780195396133.003.0011
Subject:
Neuroscience, History of Neuroscience

John Moore initially became known for elucidating the action of tetrodotoxin and other neurotoxins using his innovative sucrose gap method for voltage clamping squid axon. He also was a pioneer in ... More


Introduction

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0001
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Nerve impulses traversing the brain were likened by Sherrington to points of light in an enchanted loom. The electrochemical nature of the nerve impulse was largely elucidated by Hodgkin and Huxley ... More


The Voltage Clamp

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0015
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

Now in Chicago, Kenneth Cole employs a negative feedback circuit, devised by a colleague, to clamp the voltage across the membrane of the squid giant axon. He shows that during the action potential ... More


The Single Ion Channel

Alan J. McComas

in Galvani’s Spark: The Story of the Nerve Impulse

Published in print:
2011
Published Online:
September 2011
ISBN:
9780199751754
eISBN:
9780199897094
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199751754.003.0019
Subject:
Neuroscience, History of Neuroscience, Sensory and Motor Systems

A “gating” current, predicted by the Hodgkin-Huxley equations twenty years earlier, is finally detected in the squid giant axon. Soon after, Bert Sakmann and Erwin Neher develop a patch clamp method ... More


Control of the spatial distribution of sodium channels in the squid giant axon and its cell bodies

W. F. Gilly, M. T. Lucero, M. Perri, and J. Rosenthal

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0116
Subject:
Neuroscience, Invertebrate Neurobiology

This chapter summarizes the progress in developing a model system for studying the control of neuronal Na channel distribution based on the squid giant axon and its cell bodies located in the giant ... More


Electrophysiology of squid Schwann cells

N. Joan Abbott, E. R. Brown, Y. Pichon, and Fumio Kukita

in Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

Published in print:
1995
Published Online:
March 2012
ISBN:
9780198547907
eISBN:
9780191724299
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780198547907.003.0133
Subject:
Neuroscience, Invertebrate Neurobiology

Schwann cells are the class of glial cells of the peripheral nervous system associated with axons. The myelin-forming Schwann cells of large-diameter vertebrate axons have a clear physiological ... More


Ion channels: Principles, terminology and methodology

Derek Trezise, Tim Dale, and Martin Main

in Ion Channels: From Structure to Function

Published in print:
2009
Published Online:
March 2012
ISBN:
9780199296750
eISBN:
9780191724572
Item type:
chapter
Publisher:
Oxford University Press
DOI:
10.1093/acprof:oso/9780199296750.003.0001
Subject:
Neuroscience, Development

Ion channels are cellular proteins that conduct the movement of ions from one side of a membrane to the other. The resultant changes in local ion concentrations and electrical field play pivotal ... More


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